Winstrol is hepatotoxic, and because of this, it should be used at the lowest effective dose for the shortest possible cycle. What’s more, you should consider using a supplement designed to provide some additional protection. Milk thistle is a highly recommended option; studies suggest it can provide an effective layer of protection when it is used for the entire length of your cycle. There are some other supplements on the market, such as Liver Care, which are blends of natural ingredients that have been shown to work together to prevent liver toxicity.
Once more, an early study done on S-4 provided proof of full muscle regeneration in volunteers with with degenerative disorders without the use of exercise and the minimum dosage of 3mg/kg/day. Changes can be seen anywhere from 1-2 weeks. This was the very first study classified S-4 as CLINICALLY SIGNIFICANT by improving skeletal muscle strength, lean body mass, and a reduction in body fat [Chen et al., 2005; Gao et al., 2005; Kearbey et al., 2007]. Unfortunately, there are always some side effects that arise when using Because S-4 is a ligand by definition, the side effects will never be permanent even at supraphysiological dosages and can be easily avoided through proper dosing.