Whilst the use of inhaled steroids and long acting beta-adrenoceptor agonists (LABA) are recommended in asthma guidelines for the resulting improved symptom control,  concerns have been raised that salmeterol may increase the small risks of asthma deaths and this additional risk is not reduced with the additional use of inhaled steroids.  Other side effects from this drug combination may include increased blood pressure, change in heart rate, an irregular heartbeat, increased risk of osteoporosis, cataracts, and glaucoma. 
Flonase® is just one of several nasal spray options available in prescription form. These should be distinguished from many over-the-counter nasal spray decongestants that are not safe for long-term use, and that are sometimes abused. There is far less likelihood of this abuse with nasal corticosteroids, though clearly people need to adhere to directions for careful administration of this medicine. The bottles are created so that the same amount of spray is released each time, provided the pumping mechanism is clean, which ensures equal dosing amounts.